abstract：BACKGROUND:Scale-up of malaria interventions over the last decade have yielded a significant reduction in malaria transmission and disease burden in sub-Saharan Africa. We estimated economic gradients in the distribution of these efforts and of their impacts within and across endemic countries. METHODS:Using Demograph...

journal_title：BMC medicine

authors： Galactionova K,Smith TA,de Savigny D,Penny MA

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Wild type 2 poliovirus was last observed in 1999. The Sabin-strain oral polio vaccine type 2 (OPV2) was critical to eradication, but it is known to revert to a neurovirulent phenotype, causing vaccine-associated paralytic poliomyelitis. OPV2 is also transmissible and can establish circulating lineages, calle...

journal_title：BMC medicine

authors： McCarthy KA,Chabot-Couture G,Famulare M,Lyons HM,Mercer LD

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:Pregnancy and pregnancy loss may be linked to cardiovascular disease (CVD). However, the evidence is still inconsistent, especially in East Asians, whose reproductive patterns differ importantly from those in the West. We examined the associations of pregnancy, miscarriage, induced abortion, and stillbirth w...

journal_title：BMC medicine

authors： Peters SAE,Yang L,Guo Y,Chen Y,Bian Z,Tian X,Chang L,Zhang S,Liu J,Wang T,Chen J,Li L,Woodward M,Chen Z,China Kadoorie Biobank collaboration group.

更新日期：2017-08-08 00:00:00

abstract：BACKGROUND:Resistance and tolerance to Plasmodium falciparum can determine the progression of malaria disease. However, quantitative evidence of tolerance is still limited. We investigated variations in the adverse impact of P. falciparum infections among African pregnant women under different intensities of malaria tr...

journal_title：BMC medicine

authors： Ndam NT,Mbuba E,González R,Cisteró P,Kariuki S,Sevene E,Rupérez M,Fonseca AM,Vala A,Maculuve S,Jiménez A,Quintó L,Ouma P,Ramharter M,Aponte JJ,Nhacolo A,Massougbodji A,Briand V,Kremsner PG,Mombo-Ngoma G,Desai M,

更新日期：2017-07-17 00:00:00

abstract：BACKGROUND:In patients with stage II colorectal cancer (CRC) the number of surgically retrieved lymph nodes (LNs) is associated with prognosis, resulting in a minimum of 10-12 retrieved LNs being recommended for this stage. Current guidelines do not provide a recommendation regarding LN yield in T1 CRC. Studies evaluat...

journal_title：BMC medicine

authors： Backes Y,Elias SG,Bhoelan BS,Groen JN,van Bergeijk J,Seerden TCJ,Pullens HJM,Spanier BWM,Geesing JMJ,Kessels K,Kerkhof M,Siersema PD,de Vos Tot Nederveen Cappel WH,van Lelyveld N,Wolfhagen FHJ,Ter Borg F,Offerhaus GJA,L

更新日期：2017-07-14 00:00:00

abstract：:The damage to health caused by intimate partner violence demands effective responses from healthcare providers and healthcare systems worldwide. To date, most evidence for the few existing, effective interventions in use comes from high-income countries. Gupta et al. provide rare evidence of a nurse-delivered intimate...

journal_title：BMC medicine

authors： Taft A,Colombini M

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:The United Nation's Sustainable Development Goals for 2030 include reducing premature mortality from non-communicable diseases (NCDs) by one third. To assess the feasibility of this goal in China, we projected premature mortality in 2030 of NCDs under different risk factor reduction scenarios. METHODS:We us...

journal_title：BMC medicine

authors： Li Y,Zeng X,Liu J,Liu Y,Liu S,Yin P,Qi J,Zhao Z,Yu S,Hu Y,He G,Lopez AD,Gao GF,Wang L,Zhou M

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:The World Health Organisation (WHO) recommends parasitological diagnosis of malaria before treatment, but use of malaria rapid diagnostic tests (mRDTs) by community health workers (CHWs) has not been fully tested within health services in south and central Asia. mRDTs could allow CHWs to diagnose malaria acc...

journal_title：BMC medicine

authors： Leslie T,Rowland M,Mikhail A,Cundill B,Willey B,Alokozai A,Mayan I,Hasanzai A,Baktash SH,Mohammed N,Wood M,Rahimi HU,Laurent B,Buhler C,Whitty CJM

更新日期：2017-07-07 00:00:00

abstract：BACKGROUND:The benefit-risk balance of vaccines is regularly debated by the public, but the utility of media monitoring for regulatory bodies is unclear. A media monitoring study was conducted at the European Medicines Agency (EMA) concerning human papillomavirus (HPV) vaccines during a European Union (EU) referral pro...

journal_title：BMC medicine

authors： Bahri P,Fogd J,Morales D,Kurz X,ADVANCE consortium.

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:We aimed to show the non-inferiority of home fortification with a daily dose of 3 mg iron in the form of iron as ferric sodium ethylenediaminetetraacetate (NaFeEDTA) compared with 12.5 mg iron as encapsulated ferrous fumarate in Kenyan children aged 12-36 months. In addition, we updated a recent meta-analysi...

journal_title：BMC medicine

authors： Teshome EM,Andang'o PEA,Osoti V,Terwel SR,Otieno W,Demir AY,Prentice AM,Verhoef H

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Cognitive impairment is very common in late-life depression, principally affecting executive skills and information processing speed. The aim of the study was to examine the effect of antidepressant treatment on cognitive performances over a 10-year period. METHODS:The community-based cohort included 7381 p...

journal_title：BMC medicine

authors： Carrière I,Norton J,Farré A,Wyart M,Tzourio C,Noize P,Pérès K,Fourrier-Réglat A,Ritchie K,Ancelin ML

更新日期：2017-04-19 00:00:00

abstract：BACKGROUND:The inverse equity hypothesis asserts that new health policies initially widen inequality, then attenuate inequalities over time. Since 2004, the UK's pay-for-performance scheme for chronic disease management (CDM) in primary care general practices (the Quality and Outcomes Framework) has permitted practices...

journal_title：BMC medicine

authors： Lowrie R,McConnachie A,Williamson AE,Kontopantelis E,Forrest M,Lannigan N,Mercer SW,Mair FS

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:In adults with febrile urinary tract infection (fUTI), data on optimal treatment duration in patients other than non-pregnant women without comorbidities are lacking. METHODS:A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of reg...

journal_title：BMC medicine

authors： van Nieuwkoop C,van der Starre WE,Stalenhoef JE,van Aartrijk AM,van der Reijden TJ,Vollaard AM,Delfos NM,van 't Wout JW,Blom JW,Spelt IC,Leyten EM,Koster T,Ablij HC,van der Beek MT,Knol MJ,van Dissel JT

更新日期：2017-04-03 00:00:00

abstract：BACKGROUND:International medical graduates working in the UK are more likely to be censured in relation to fitness to practise compared to home graduates. Performance on the General Medical Council's (GMC's) Professional and Linguistic Assessments Board (PLAB) tests and English fluency have previously been shown to pre...

journal_title：BMC medicine

authors： Tiffin PA,Paton LW,Mwandigha LM,McLachlan JC,Illing J

更新日期：2017-03-20 00:00:00

abstract：:Although clinical nutrition is a frequently used intervention in inpatient care, high quality trials proving its effectiveness and safety when used in the acutely-ill polymorbid medical inpatient population are largely lacking. From an evolutionary perspective, illness-related low appetite is protective and part of th...

journal_title：BMC medicine

authors： Schuetz P

更新日期：2017-02-24 00:00:00

abstract：:The microbes colonizing the infant gastrointestinal tract have been implicated in later-life disease states such as allergies and obesity. Recently, the medical research community has begun to realize that very early colonization events may be most impactful on future health, with the presence of key taxa required for...

journal_title：BMC medicine

authors： Ward TL,Knights D,Gale CA

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely available, safe and relatively low cost tools and analyses recent work highlighting their potential utili...

journal_title：BMC medicine

authors： Malojcic B,Giannakopoulos P,Sorond FA,Azevedo E,Diomedi M,Oblak JP,Carraro N,Boban M,Olah L,Schreiber SJ,Pavlovic A,Garami Z,Bornstein NM,Rosengarten B

更新日期：2017-02-09 00:00:00

abstract：BACKGROUND:The prevalence of non-communicable diseases (NCDs) is increasing in sub-Saharan Africa. At the same time, the use of mobile phones is rising, expanding the opportunities for the implementation of mobile phone-based health (mHealth) interventions. This review aims to understand how, why, for whom, and in what...

journal_title：BMC medicine

authors： Opoku D,Stephani V,Quentin W

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Strategies in many countries have sought to improve palliative care and reduce hospital deaths for non-cancer patients, but their effects are not evaluated. We aimed to determine the trends and factors associated with dying in hospital in two common progressive respiratory diseases, and the impact of a natio...

journal_title：BMC medicine

authors： Higginson IJ,Reilly CC,Bajwah S,Maddocks M,Costantini M,Gao W,GUIDE_Care project.

更新日期：2017-02-01 00:00:00

abstract：:Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, wi...

journal_title：BMC medicine

authors： Mijajlović MD,Pavlović A,Brainin M,Heiss WD,Quinn TJ,Ihle-Hansen HB,Hermann DM,Assayag EB,Richard E,Thiel A,Kliper E,Shin YI,Kim YH,Choi S,Jung S,Lee YB,Sinanović O,Levine DA,Schlesinger I,Mead G,Milošević V,Ley

更新日期：2017-01-18 00:00:00

abstract：:Intra-tumour heterogeneity is a common molecular phenomenon in metastatic clear cell renal carcinoma (mRCC), representing the genetic complexity of a tumour with multiple metastatic sites. The present commentary discusses the observed phenomena of phenotypic intra-tumour heterogeneity in mRCC patients treated with the...

journal_title：BMC medicine

authors： Stühler V,Bedke J

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Although nut consumption has been associated with a reduced risk of cardiovascular disease and all-cause mortality, data on less common causes of death has not been systematically assessed. Previous reviews missed several studies and additional studies have since been published. We therefore conducted a syst...

journal_title：BMC medicine

authors： Aune D,Keum N,Giovannucci E,Fadnes LT,Boffetta P,Greenwood DC,Tonstad S,Vatten LJ,Riboli E,Norat T

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Publication bias and other reporting bias have been well documented for journal articles, but no study has evaluated the nature of results posted at ClinicalTrials.gov. We aimed to assess how many randomized controlled trials (RCTs) with results posted at ClinicalTrials.gov report statistically significant r...

journal_title：BMC medicine

authors： Dechartres A,Bond EG,Scheer J,Riveros C,Atal I,Ravaud P

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:The term 'lower value services' concerns healthcare that is of little or no value to the patient and consequently should not be provided routinely, or not be provided at all. De-adoption of lower value care may occur through explicit recommendations in clinical guidelines. The present study aimed to generate...

journal_title：BMC medicine

authors： Wammes JJ,van den Akker-van Marle ME,Verkerk EW,van Dulmen SA,Westert GP,van Asselt AD,Kool RB

更新日期：2016-11-25 00:00:00

abstract：:How should we approach trial design when we can get some, but not all, of the way to the numbers required for a randomised phase III trial?We present an ordered framework for designing randomised trials to address the problem when the ideal sample size is considered larger than the number of participants that can be r...

journal_title：BMC medicine

authors： Parmar MK,Sydes MR,Morris TP

更新日期：2016-11-25 00:00:00

abstract：:Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, pa...

journal_title：BMC medicine

authors： Fisher D,Cutter J

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality prediction: body surface area adjusted-Cockcroft-Gault (CG-BSA), Modification of Diet in Renal Disease...

journal_title：BMC medicine

authors： Ferreira JP,Girerd N,Pellicori P,Duarte K,Girerd S,Pfeffer MA,McMurray JJ,Pitt B,Dickstein K,Jacobs L,Staessen JA,Butler J,Latini R,Masson S,Mebazaa A,Rocca HP,Delles C,Heymans S,Sattar N,Jukema JW,Cleland JG,Za

更新日期：2016-11-10 00:00:00

abstract：BACKGROUND:The prognostic significance of tumor-associated macrophages (TAM) in adult classical Hodgkin lymphoma (cHL) remains controversial. Here, we report a meta-analysis of the association of CD68 and CD163 infiltration on the clinical outcome of adult cHL. METHODS:A comprehensive search to identify relevant artic...

journal_title：BMC medicine

authors： Guo B,Cen H,Tan X,Ke Q

更新日期：2016-10-17 00:00:00

abstract：BACKGROUND:The UK Clinical Aptitude Test (UKCAT) has been shown to have a modest but statistically significant ability to predict aspects of academic performance throughout medical school. Previously, this ability has been shown to be incremental to conventional measures of educational performance for the first year of...

journal_title：BMC medicine

authors： Tiffin PA,Mwandigha LM,Paton LW,Hesselgreaves H,McLachlan JC,Finn GM,Kasim AS

更新日期：2016-09-26 00:00:00

abstract：:Due to the easier access to information, the availability of low cost technologies and the involvement of well educated, passionate patients, a group of citizen 'Health Hackers', who are building their own medical systems to help them overcome the unmet needs of their conditions, is emerging. This has recently been th...

journal_title：BMC medicine

authors： Omer T

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Pneumonia in people with dementia has been associated with severe discomfort. We sought to assess the effectiveness of a practice guideline for optimal symptom relief for nursing home residents with dementia and pneumonia. METHODS:A single-blind, multicenter, cluster randomized controlled trial was conducte...

journal_title：BMC medicine

authors： van der Maaden T,de Vet HC,Achterberg WP,Boersma F,Schols JM,Mehr DR,Galindo-Garre F,Hertogh CM,Koopmans RT,van der Steen JT

更新日期：2016-08-11 00:00:00

abstract：:There has been increasing interest in the role of malaria drugs in preventing malaria transmission from humans to mosquitoes, which would help augment malaria control and elimination strategies. Nevertheless, only one stage in the malaria parasite life cycle, the gametocyte, is infectious to mosquitoes. The Worldwide ...

journal_title：BMC medicine

authors： Karunajeewa HA,Mueller I

更新日期：2016-06-18 00:00:00

abstract：BACKGROUND:The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS:We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database of...

journal_title：BMC medicine

authors： Bruce R,Chauvin A,Trinquart L,Ravaud P,Boutron I

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Extended use of combined pharmacotherapies to treat tobacco dependence may increase smoking abstinence; few studies have examined their effectiveness. The objective of this study was to evaluate smoking abstinence with standard nicotine patch (NRT), extended use of combined formulations of nicotine replaceme...

journal_title：BMC medicine

authors： Tulloch HE,Pipe AL,Els C,Clyde MJ,Reid RD

更新日期：2016-06-07 00:00:00

abstract：BACKGROUND:Clinicians have known for centuries that there is substantial variability between patients in their response to medications-some individuals exhibit a miraculous recovery while others fail to respond at all. Still others experience dangerous side effects. The hunt for the factors responsible for this variati...

journal_title：BMC medicine

authors： Nayak RR,Turnbaugh PJ

更新日期：2016-05-04 00:00:00

abstract：:The diagnosis of multidrug resistant tuberculosis (MDR-TB) in any individual is the beginning of a prolonged and difficult therapeutic journey. It also marks the moment from which to begin consideration of how to manage close contacts. Preventive therapy for drug-susceptible latent tuberculosis infection has been demo...

journal_title：BMC medicine

authors： Moore DA

更新日期：2016-04-01 00:00:00

abstract：:In recent years, the introduction and Federal Drug Administration approval of immune checkpoint inhibitor antibodies has dramatically improved the clinical outcomes for patients with advanced melanoma. These antagonist monoclonal antibodies are capable of unleashing dormant or exhausted antitumor immunity, which has l...

journal_title：BMC medicine

authors： Redman JM,Gibney GT,Atkins MB

更新日期：2016-02-06 00:00:00

abstract：BACKGROUND:Multiple treatments are frequently available for a given condition, and clinicians and patients need a comprehensive, up-to-date synthesis of evidence for all competing treatments. We aimed to quantify the waste of research related to the failure of systematic reviews to provide a complete and up-to-date evi...

journal_title：BMC medicine

authors： Créquit P,Trinquart L,Yavchitz A,Ravaud P

更新日期：2016-01-20 00:00:00

abstract：BACKGROUND:The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests resistance to both artemisinin and piperaquine. Available in vitro piperaquine susceptibility assays do not correlate with treatment outcome. A nov...

journal_title：BMC medicine

authors： Duru V,Khim N,Leang R,Kim S,Domergue A,Kloeung N,Ke S,Chy S,Eam R,Khean C,Loch K,Ken M,Lek D,Beghain J,Ariey F,Guerin PJ,Huy R,Mercereau-Puijalon O,Witkowski B,Menard D

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Predicting treatment benefit and/or outcome before any therapeutic intervention has taken place would be clinically very useful. Herein, we evaluate the ability of the intrinsic subtypes and the risk of relapse score at diagnosis to predict survival and response following neoadjuvant chemotherapy. In additio...

journal_title：BMC medicine

authors： Prat A,Fan C,Fernández A,Hoadley KA,Martinello R,Vidal M,Viladot M,Pineda E,Arance A,Muñoz M,Paré L,Cheang MC,Adamo B,Perou CM

更新日期：2015-12-18 00:00:00